Ubiquitin conjugating enzyme E2 F (UBE2F), also known as NEDD8-conjugating enzyme 2 (NCE2) or MGC18120, is encoded by the gene mapped to human chromosome 2q37.3.
Immunogen
Peptide with sequence CHLRDKEDFRNKVDD, from the C-Terminus of the protein sequence according to NP_542409.1.
Biochem/physiol Actions
Ubiquitin conjugating enzyme E2 F (UBE2F) acts as a neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-conjugating enzyme E2 in the neddylation cascade. It activates the polyubiquitin synthesis of cullin RING (really interesting new gene) ligase viral infectivity factor (CRL5Vif)-core binding factor β (CBFβ) complex in vitro.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.
Chung d and Dellaire G
Biomolecules (2015)
What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?
Michelle C
Journal of Molecular Evolution (2009)
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.
Stanley DJ
PLoS Pathogens (2012)
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