Membrane spanning 4-domains A1 (MS4A1), also referred to as cluster of differentiation 20 (CD20), is expressed on the surface of human B lymphocytes and on a small subset of T cells. The 33-35kDa, non-glycosylated protein has four membrane-spanning domains with both the amino and carboxy termini of the protein localized to the cytoplasm, and a short 43 residue-extracellular segment. It is part of the membrane-spanning 4A gene family. The gene encoding MS4A1 is localized on human chromosome 11q12-13.
Immunogen
Peptide with sequence CQDQESSPIENDSSP, from the C Terminus of the protein sequence according to NP_068769.2; NP_690605.1.
Biochem/physiol Actions
Membrane spanning 4-domains A1 (MS4A1) or CD20 participates in the development and cell cycle progression in B-cells. It has been found to interact with proteins like adapter protein p75/80, CD40 and major histocompatibility complex class II proteins (MHC II). It may participate in Ca2+ influx across plasma membranes, maintenance of Ca2+ concentration and activation of B-cells. CD20 activates Src leading to rapid phosphorylation of phospholipase C-γ1 (PLC-γ1) and PLC-γ2, in turn activating caspase-3 signaling of apoptosis.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Aneuploidy should compromise cellular proliferation but paradoxically favours tumour progression and poor prognosis. Here, we consider this paradox in terms of our most recent observations of chemo/radio-resistant cells undergoing reversible polyploidy. The latter perform the segregation of two parental groups
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