Renalase (RNLS) is an intracellular flavin adenine dinucleotide-dependent amine oxidase. This flavoprotein′s amino-terminal peptide sequence is necessary for FAD accommodation. It is secreted by the kidney into the blood. RNLS is also expressed in the heart, skeletal muscle and small intestine. The gene encoding this protein consists of nine exons and is localized on human chromosome 10q23.33.
Immunogen
Peptide with sequence C-VSIDNKKRNI from the internal region of the protein sequence according to NP_001026879.1; NP_060833.1.
Biochem/physiol Actions
Renalase (RNLS) modulates blood pressure and cardiac activities. It reduces circulating catecholamines. Patients with end-stage renal disease have reduced concentrations of renalase in the plasma.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
Xu J
The Journal of Clinical Investigation (2005)
Renalase gene polymorphism is associated with increased blood pressure in preeclampsia.
Bagci B
Pregnancy hypertension (2016)
Renalase Secreted by Human Kidney HEK293T Cells Lacks its N-Terminal Peptide: Implications for Putative Mechanisms of Renalase Action.
Fedchenko V
Kidney & Blood Pressure Research (2016)
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