SAB2500422

Anti-FOXP3/Scurfin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-AIID, Anti-Forkhead box P3, Anti-IPEX, Anti-JM2, Anti-SCURFIN
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable; immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: Q9BZS1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FOXP3(50943)

Description

General description

Forkhead box P3 (FOXP3) is a transcription factor and part of the forkhead family. It possesses three α helices and three β strands. The protein has an amino-terminal region, a central zinc finger, a leucine zipper domain and the carboxyl-terminal region has a forkhead domain. The gene encoding this protein is localized on human chromosome Xp11.23.

Immunogen

Peptide with sequence SQRPSRCSNPTPGP from the C Terminus of the protein sequence according to NP_054728.2.

Biochem/physiol Actions

Forkhead box P3 (FOXP3) associates with nuclear factor of activated T cells (NFAT) and nuclear factor κ B (NF-κB). It has a crucial role in the cellular differentiation of regulatory T cells. Alterations in the protein expression have been associated with immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. FOXP3 has a role in tumor growth and cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable