Dual specificity phosphatase 1 (DUSP1) is a protein phosphatase. The gene encoding it is localized on human chromosome 5q35.1.
Immunogen
Peptide with sequence SYLQSPITTSPSC from the C Terminus of the protein sequence according to NP_004408.1.
Application
Anti-DUSP1 antibody produced in goat has been used for Western blotting.
Biochem/physiol Actions
Dual specificity phosphatase 1 (DUSP1) modulates the activity of mitogen-activated protein kinase (MAPK). It targets and dephosphorylates extracellular signal-regulated kinases 1 and 2 (ERK 1/2). During cellular responses to oxidative stress, the activity of DUSP1 is regulated by p53. Overexpression of the protein has been associated with various tumors.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Frontiers in pharmacology, 8, 646-646 (2017-10-07)
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE2 production in inflammation. Dexamethasone is known to suppress mPGES-1 but the mechanisms regulating mPGES-1 expression remain poorly known. MKP-1 is a phosphatase controlling
British journal of pharmacology, 169(7), 1525-1536 (2013-07-16)
3',5'-Cyclic nucleotide PDE4 is expressed in several inflammatory and immune cells, and PDE4 catalyses the hydrolysis of cAMP to 5'AMP, down-regulating cAMP signalling in cells. MAPK phosphatase-1 (MKP-1) is an endogenous p38 MAPK signalling suppressor and limits inflammatory gene expression
International immunopharmacology, 71, 139-143 (2019-03-22)
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyses the formation of PGE2 in inflammatory tissues. It is considered a potential drug target in inflammatory conditions to achieve clinical benefits comparable to NSAIDs with a better tolerability. Inhibitors of mPGES-1 are under development
PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase-1 by a mechanism dependent on MAP kinase phosphatase-1
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