CHRNA4 (cholinergic receptor nicotinic α4 subunit) encodes the α4 subunit of α4/β2-containing receptors. This gene is ~17 kb long and has six exons. CHRNA4 is located on human chromosome 20q13.2–13.3.
Immunogen
Peptide with sequence C-HVETRAHAEERLLKK from the internal region of the protein sequence according to NP_000735.1.
Biochem/physiol Actions
CHRNA4 (cholinergic receptor nicotinic α 4 subunit) plays an important role in ND (nicotine dependence). Mutations in CHRNA4 is linked with PIU (problematic internet use). In adult males, polymorphism in CHRNA4 is associated with depression and loneliness.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ethnic-and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence.
Li M D, et al.
Human Molecular Genetics, 14(9), 1211-1219 (2005)
Association of common polymorphisms in the nicotinic acetylcholine receptor alpha4 subunit gene with an electrophysiological endophenotype in a large population-based sample.
Mobascher A, et al.
PLoS ONE, 11(4), e0152984-e0152984 (2016)
The association between the nicotinic acetylcholine receptor ?4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.
Jeong JE, et al.
PLoS ONE, 12(12), e0188358-e0188358 (2017)
Association of CHRNA4 polymorphism with depression and loneliness in elderly males.
Tsai S J, et al.
Genes, Brain, and Behavior, 11(2), 230-234 (2012)
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