Arginase 1 (ARG1) gene with eight exons and seven introns, spanning 10-15kb on genomic DNA, is localized on human chromosome 6q23.2. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney.
Immunogen
Peptide with sequence C-REGNHKPIDYLNPPK from the C Terminus of the protein sequence according to NP_000036.2.
Biochem/physiol Actions
Arginase 1 (ARG1) is a liver enzyme involved in the hydrolysis of arginine to form ornithine and urea. In addition to urea cycle, ARG1 is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury. Deficiency or mutations in the gene leads to a rare urea cycle disorder, argininemia.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency
Martina Huemer
Journal of inherited metabolic disease (2016)
Carbon nanotube-based sensing devices for human Arginase-1 detection
S. Baldo
Sensing and Bio-Sensing Research (2016)
Five Novel Mutations in ARG1 Gene in Chinese Patients of Argininemia
Tong-Fei Wu
Pediatric Neurology, 49(2) (2013)
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