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Key Documents

SAB2107213

Sigma-Aldrich

Anti-TRMT6 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CGI-09, GCD10, General control non-derepressible protein 10

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

56 kDa

species reactivity

human, mouse, dog, rat, bovine, pig, rabbit, horse

technique(s)

western blot: suitable

NCBI accession no.

NM_015939

UniProt accession no.

Q9UJA5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRMT6(51605)

General description

tRNA methyltransferase 6 (TRMT6), also known as GCD10 (General control non-derepressible protein 10), is a 54.6 kDa protein. The gene is located on human chromosome 20p12.3.

Immunogen

Synthetic peptide directed towards the middle region of human TRMT6

Biochem/physiol Actions

tRNA methyltransferase 6 (TRMT6), also known as GCD10 (General control non-derepressible protein 10), is essential for initiating protein synthesis. TRMT6 encoded polypeptide is required for cell viability and consists of a sequence related to the RNA-recognition motif, which is found in many RNA-binding proteins. It helps in DNA methylation. Mutations in TRMT6 along with other genes might be linked to tumorigenesis. It acts as a translational repressor of (general control protein) GCN4.

Sequence

Synthetic peptide located within the following region: GAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDS

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC27824

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Frameshift mutations in repeat sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 genes in colon cancers
Yeon SY et al.
Pathology Oncology Research, 24(3), 617-622 (2018)
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.
Garcia-Barrio MT et al.
Genes & Development, 9(14), 1781-1796 (1995)
Fange Liu et al.
Cell, 167(3), 816-828 (2016-10-22)
tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
He C et al.
Nature Genetics, 41(6), 724-724 (2009)

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