Golgi internal membrane protein 4 (GOLIM4) is a golgi type II transmembrane phosphoprotein. In human chromosome, the gene GOLIM4 is located on 3q26.2.
Immunogen
The immunogen for anti-GOLIM4 antibody: synthetic peptide derected towards the C terminal of human GOLIM4
Biochem/physiol Actions
Golim4 plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. Golim4 plays a major role in maintaining manganese homeostasis. The expression level of Golim4 is less in cancer cells. GOLIM4 is a potential oncogene, regulates cell cycle and apoptosis in neck and cancer cells.
Sequence
Synthetic peptide located within the following region: DPGNRQEFHEPGHQEGDPEAEADRAAAQDINPADDPNNQGEDEFEEAEQV
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis. BACE1 has been studied principally for its role in Alzheimer's disease as the beta-secretase
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