Insulin gene enhancer binding protein-1 (ISL-1) gene spanning 220kb of genomic DNA, is mapped to human chromosome 5q11.1. The gene codes for a member of LIM zinc-binding/homeobox-domain transcription factor and is predominantly expressed in hindbrain, forebrain, ventral neural tube, dorsal root ganglia (DRG) and trigeminal ganglia.
Immunogen
ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Insulin gene enhancer binding protein-1 (ISL-1) is a transcription factor which plays a vital role in the development of the heart, motor neurons and pancreas. It also stimulates adult pancreatic ß-cells proliferation. ISL1 might also be involved in the regulation of insulin expression. Elevated expression of the gene has been observed in patients with gastric cancer. Thus, the protein can be used as a potential biomarker and therapeutic target for gastric cancer. Mutation in the gene is associated with the increased risk of susceptibility to human congenital heart disease (CHD).
Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy
Draaken M
PLoS Genetics, 11 (2015)
Common variation in ISL1 confers genetic susceptibility for human congenital heart disease.
Stevens KN
PLoS ONE, 5 (2010)
An abnormally high expression of ISL-1 represents a potential prognostic factor in gastric cancer.
Guo C
Human Pathology, 46, 1282-1289 (2015)
A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.
Bach I
Genes & Development, 11, 1370-1380 (1997)
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