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SAB1407796

Sigma-Aldrich

Anti-KIAA1456, (N-terminal) antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

FLJ36980, KIAA1456, MGC43113

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50 μG
$541.00

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
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50 μG
$541.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~41.5 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

NM_020844

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... C8orf79(57604)

General description

Mouse polyclonal antibody raised against a full-length human KIAA1456 protein. The gene KIAA1456 is mapped to human chromosome 8. It has an SAM (S-adenosyl methionine)-dependent methyltransferase domain.[1]

Immunogen

KIAA1456 (NP_065895, 1 a.a. ~ 367 a.a) full-length human protein.

Sequence
MVCDNLNLPFRDEGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRRFEKQDVLVPWNRALCSQLFSESSQSGRKRQCGYPERGHPYHPPCSECSCSVCFKEQGGSKRSHSVGYEPAMARTCFANISKEGEEEYGFYSTLGKSFRSWFFSRSLDESTLRKQIERVRPLKNTEVWASSTVTVQPSRHSSLDFDHQEPFSTKEQSLDEEVFVESSSGKHLEWLRAPGTLKHLNGDHQGEMRRNGGGNFLDSTNTGVNCVDAGNIEDDNPSASKILRRISAVDSTDFNPDDTMSVEDPQTDVLDSTAFMRYYHVFREGELCSLLKENVSELRILSSGNDHGNWCIIAEKKGGCD

Biochem/physiol Actions

KIAA1456 might be involved in the regulation of the translation of specific protein(s) via the methyltransferase activity. It negatively regulates tumor growth and the mRNA is downregulated in breast, bladder, colorectal, cervical and testicular carcinomas.[1]

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
09085

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Ulrike Begley et al.
EMBO molecular medicine, 5(3), 366-383 (2013-02-06)
Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a

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