MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq)
Potassium calcium activated channel subfamily M regulatory β subunit 4 (KCNMB4) is mapped to human chromosome 12q14.1-15. The encoded protein is a member of the potassium channel β subunit family. KCNMB4 contains two transmembrane segments (TM1 and TM2), intracellular N and C terminal and a large extracellular loop. It is mainly expressed in the brain, neuronal tissue, kidney and bladder smooth muscle.
Immunogen
KCNMB4 (NP_055320.4, 1 a.a. ~ 210 a.a) full-length human protein.
Potassium calcium activated channel subfamily M regulatory α subunit 4 (KCNMB4) plays a vital role in increasing Ca2+ sensitivity. It reduces the voltage dependence of the conductance-voltage relationship as well as the slope of the gating charge-voltage curve.
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
Torres YP, et al.
Frontiers in Physiology, 5, 383-383 (2014)
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large?conductance calcium?activated potassium channel β subunit family
Behrens R, et al.
Febs Letters, 474(1), 99-106 (2000)
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