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Key Documents

SAB1407352

Sigma-Aldrich

Anti-VENTX antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

HPX42B, MGC119910, MGC119911, NA88A, VENTX2

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50 μG
$541.00

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
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50 μG
$541.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~27.6 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

NM_014468.2

UniProt accession no.

O95231

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VENTX(27287)

General description

This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas (provided by RefSeq). Vent homeobox (VENTX) is a human homeobox transcription factor. VENTX is majorly expressed in human myeloid cells. VENTX gene is located on human chromosome 10q26.3.

Immunogen

VENTX (NP_055283.1, 1 a.a. ~ 258 a.a) full-length human protein.

Sequence
MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF

Biochem/physiol Actions

Vent homeobox(VENTX) regulates proliferation and differentiation of hematopoietic cells.VENTX acts as a tumor suppressor and plays an important role in proinflammatory activation.Dysregulation of VENTX may contribute to pathogenesis of autoimmune diseases.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
08281

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Homeobox transcription factor VentX regulates differentiation and maturation of human dendritic cells
Wu X, et al.
The Journal of Biological Chemistry, M113-M113 (2014)
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
Wu X, et al.
The Journal of Clinical Investigation, 121(7) (2011)
VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice
Gentner E, et al.
Oncotarget, 7(52), 86889-86889 (2016)
Homeobox protein VentX induces p53-independent apoptosis in cancer cells
Gao H, et al.
Oncotarget, 7(26), 39719-39719 (2016)
Classification and nomenclature of all human homeobox genes
Holland PWH, et al.
BMC Biology, 5(1), 47-47 (2007)

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