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Key Documents

SAB1406719

Sigma-Aldrich

Anti-RAB11A antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

MGC1490, YL8

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50 μG
$541.00

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
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50 μG
$541.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$541.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~24.4 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_004663

UniProt accession no.

P62491

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB11A(8766)

General description

Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is a GTP binding protein. RAB11A gene is located on human chromosome 15q21.3. RAB11A is expressed abundantly in tissues with high secretion.

Immunogen

RAB11A (NP_004654.1, 1 a.a. ~ 216 a.a) full-length human protein.

Sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI

Biochem/physiol Actions

Ras-related protein Rab-11A (RAB11A), member RAS oncogene family, is involved in vesicle trafficking during recycling of endosomes. Overexpression of RAB11A leads to an increased collective cell invasion in colorectal carcinoma.RAB11A and its binding partners plays a crucial role in recycling of human β1-adrenergic receptor.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
09184

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Rab11a and its binding partners regulate the recycling of the ss1-adrenergic receptor
Gardner LA, et al.
Cellular Signalling, 23(1), 46-57 (2011)
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma
Chung YC, et al.
European Journal of Clinical Investigation, 46(12), 1002-1011 (2016)
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis
Gebhardt C, et al.
The American Journal of Pathology, 167(1), 243-253 (2005)
Molecular mechanism of constitutively active Rab11A was revealed by crystal structure of Rab11A S20V
Choi JY, et al.
Febs Letters, 590(6), 819-827 (2016)
Kazumori Kawakami et al.
Oncology reports, 16(3), 521-531 (2006-07-26)
Large-scale gene expression profiling is an effective strategy for understanding the progression of bladder cancer (BC). The aim of this study was to identify genes that are expressed differently in the course of BC progression and to establish new biomarkers

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