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SAB1406267

Sigma-Aldrich

Anti-PLSCR1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

MMTRA1B

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~35 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_021105.1

UniProt accession no.

O15162

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PLSCR1(5359)

General description

Phospholipid scramblase 1 (PLSCR1) is a 35kDa calcium dependant phospholipid translocator. The gene is located on human chromosome 3q24. The protein is overexpressed in tumor cells.

Immunogen

PLSCR1 (NP_066928.1, 1 a.a. ~ 318 a.a) full-length human protein.

Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW

Biochem/physiol Actions

Phospholipid scramblase 1 (PLSCR1) bidirectionally transfers lipids across the membranes. It negatively regulates autophagy in mantle cell lymphoma (MCL). This protein is known to scramble phospholipids in the plasma membrane and thereby, disrupt membrane asymmetry. It functions as a multifunctional signalling molecule. It also has nuclease activity. PLSCR1 plays a role in cell proliferation, differentiation, apoptosis, pathogenesis of cancers, particularly leukemia.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
Sivagnanam U, et al.
BMC Biochemistry, 17(1), 10-10 (2016)
Biochemical evidence for Ca2+-independent functional activation of hPLSCR1 at low pH
Francis VG, et al.
Cellular & Molecular Biology Letters, 20(2), 177-195 (2015)
Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites
Girirajan S, et al.
Genome Research (2009)
Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma
Mastorci K, et al.
Oncotarget, 7(27), 41913-41913 (2016)
Phospholipid scramblase 1
Huang Y, et al.
Sheng li xue bao : [Acta physiologica Sinica], 58(6), 501-510 (2006)
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