This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. (provided by RefSeq)
Immunogen
DNASE1 (NP_005214, 1 a.a. ~ 282 a.a) full-length human protein.
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Journal of assisted reproduction and genetics, 33(12), 1657-1664 (2016-09-16)
To verify if the presence of varicocele (grades II and III) with and without seminal alterations, using the 5 This cross sectional study was performed at the Sao Paulo Federal University Paulo between May 2014 and April 2016. A total
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