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SAB1403470

Sigma-Aldrich

Monoclonal Anti-BNIPL, (N-terminal) antibody produced in mouse

clone 2C8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, PP753

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2C8, monoclonal

form

buffered aqueous solution

mol wt

antigen ~56.36 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

BC027868

UniProt accession no.

Q7Z465

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BNIPL(149428)

Related Categories

General description

The gene BNIPL (Bcl-2/adenovirus E1B 19kDa interacting protein 2-like) encodes a protein containing BNIP-2 and Cdc42GAP homology (BCH) domain and has a molar mass of 19kDa. It is abundantly expressed in human placenta and lung.

Immunogen

BNIPL (AAH27868, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT

Biochem/physiol Actions

The gene BNIPL (Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like) encodes a protein of the BNIPL family that functions in the apoptotic pathway. The BCH (BNIP-2 and Cdc42GAP homology) domain plays a crucial role by interacting with Bcl-2 and Cdc42GAP and inducing cell death. It serves as a linker protein in Bcl-2 pathway for DNA fragmentation. It also participates in Cdc42 (cell division control) signaling for changes in cell morphology and membrane blebbing during apoptosis. It facilitates invasion and cancer metastasis.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells.
Xie L
Oncology Reports, 17, 605-610 (2007)
Li Shen et al.
FEBS letters, 540(1-3), 86-90 (2003-04-12)
Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like, BNIP-2-like (BNIPL) is a recently cloned and characterized apoptosis-associated protein that shares 72% homology with BNIP-2. It is highly expressed in human placenta and lung. A yeast two-hybrid system was used to obtain
Wenxin Qin et al.
Biochemical and biophysical research communications, 308(2), 379-385 (2003-08-07)
The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family

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