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Key Documents

SAB1403423

Sigma-Aldrich

Monoclonal Anti-SCGB3A1 antibody produced in mouse

clone 3G5, purified immunoglobulin, buffered aqueous solution

Synonym(s):

HIN-1, HIN1, LU105, MGC87867, PnSP-2, UGRP2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3G5, monoclonal

form

buffered aqueous solution

mol wt

antigen ~37.55 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable

isotype

IgG2aκ

NCBI accession no.

BC029176

UniProt accession no.

Q96QR1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SCGB3A1(92304)

General description

Secretoglobin family 3A member 1 (SCGB3A1) is a member of secretoglobin gene super family, which contains small secretory proteins. SCGB3A1 is expressed mainly in the epithelial organs, such as the lungs, breast glands, trachea, prostate and salivary glands. SCGB3A1 gene is located on human chromosome 5q35.3.

Immunogen

SCGB3A1 (AAH29176, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MKLAALLGLCVALSCSSAAAFLVGSAKPVAQPVAALESAAEAGAGTLANPLGTLNPLKLLLSSLGIPVNHLIEGSQKCVAELGPQAVGAVKALKALLGALTVFG

Biochem/physiol Actions

Secretoglobin family 3A member 1 (SCGB3A1) plays an important role in cell growth, migration and invasion as a potent inhibitor and these activities are mediated through protein kinase B (PKB/AKT) signal pathway. Aberrant mutations of SCGB3A1 may be used as a prognostic marker for breast cancer and other human malignancies. SCGB3A1 is used as an epigenetic marker for therapy selection in glioblastoma multiforme (GBM). SCGB3A1 plays an important role in inflammation.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
08144-3G5

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Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression
Tomita T, et al.
BMC Molecular Biology, 9(1), 5-5 (2008)
High-resolution genome-wide analysis of chromosomal alterations in elastofibroma
Hernandez J L G , et al.
Virchows Archiv, 456(6) (2010)
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies
Shigematsu H, et al.
International Journal of Cancer. Journal International Du Cancer, 113(4) (2005)
Aberrant promoter methylation of HIN-1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis
Dai D, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(8) (2014)
HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme
Herranz M, et al.
Molecular Neurobiology, 53(3) (2016)
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