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Key Documents

SAB1402046

Sigma-Aldrich

Anti-PTPLB antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

3-Hydroxyacyl-CoA dehydratase 2, HACD2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_198402.2

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PTPLB(201562)

General description

Protein tyrosine phosphatase-like member b gene (PTPLB) is an integral protein of endoplasmic reticulum, with four membrane-spanning alpha helices. PTPLB is also known as 3-hydroxyacyl-CoA dehydratase 2 (HACD2).

Immunogen

PTPLB (NP_940684.1, 1 a.a. ~ 254 a.a) full-length human protein.

Sequence
MAAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKKFE

Biochem/physiol Actions

Protein tyrosine phosphatase-like member b gene (PTPLB) catalyses the third step in the elongation of fatty acid synthesis. It catalyses the dehydration of the 3-hydroxyacyl-CoA.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
09112

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The role of fatty acid elongation in epidermal structure and function
Uchida and Yoshikazu.
Dermato-endocrinology, 3(2) (2011)
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways
Sawai, et al.
The Journal of Biological Chemistry (2017)
The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B
Wang, et al.
Molecular and Cellular Biology, 24(7) (2004)
Mika Ikeda et al.
FEBS letters, 582(16), 2435-2440 (2008-06-17)
Very long-chain fatty acids are produced through a four-step cycle. However, the 3-hydroxyacyl-CoA dehydratase catalyzing the third step in mammals has remained unidentified. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3

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