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SAB1401241

Sigma-Aldrich

Anti-MEF2C antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MEF2C(4208)

Immunogen

MEF2C (AAH26341.1, 1 a.a. ~ 469 a.a) full-length human protein.

Sequence
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEQHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMQPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSE

Biochem/physiol Actions

MEF2C (myocyte enhancer factor 2C) is a cardiac and smooth muscle-specific transcription factor. It positively regulates the transcriptional activation induced by myocardin. Thus, it coordinates the smooth muscle cell differentiation. MEF2C is associated with nuclear factor of activated T-cells (NFAT) and upregulation of the gene is observed in mitral regurgitation. In retina, the MEF2C regulates the expression of photoreceptor gene.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression.
Wolf A
Biochemical and Biophysical Research Communications, 483(1), 346-351 (2017)
Transcriptome and Metabolome Analyses in Exogenous FABP4- and FABP5-Treated Adipose-Derived Stem Cells.
Yamamoto T
PLoS ONE, 11(12), 1-19 (2016)
ABCG1 and ABCG4 Suppress ?-Secretase Activity and Amyloid ? Production.
Sano O
PLoS ONE, 11(5), 1-19 (2016)

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