SAB1306189

ANTI-IDDM12(N-TERMINAL) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): CD152, CD_antigen=CD152, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 24656 Da
• species reactivity: human
• technique(s): immunohistochemistry: 1:50-1:100; western blot: 1:2000
• NCBI accession no.: NP_001032720.1
• UniProt accession no.: P16410
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CTLA4(1493)

Description

General description

CTLA4 (cytotoxic T-lymphocyte associated protein 4), also known as IDDM12 or CD152 (cluster of differentiation), is a T cell receptor which belongs to the immunoglobulin (Ig) superfamily. It is expressed on the surface of T helper cells. This gene is localized to human chromosome 2q33. This protein is composed of a cytosolic domain, a transmembrane region and a V domain of 116 amino acids. Alternative splicing of IDDM12 results in membrane and soluble forms. The membrane form works as homodimers and the soluble isoforms work as monomers.

Biochem/physiol Actions

CTLA4 (cytotoxic T-lymphocyte associated protein 4) or insulin dependent diabetes mellitus 12 (IDDM12) is responsible for inhibiting T-cell proliferation and facilitates T cell apoptosis. This protein is expressed post-antigen presentation and thus, is involved in immune and autoimmune disorders. It is implicated in the pathogenesis of various T cell mediated autoimmune disorders.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable