LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 β) is a homolog of the ATG8 gene, which is an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I.
Biochem/physiol Actions
MAP1LC3B-I (microtubule associated protein 1 light chain 3 β-I) associates with MAP1LC3B-II before being inserted into the inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. MAP1LC3B can serve as an autophagic marker.
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Supplied in PBS with 0.09% (W/V) sodium azide
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Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
Swaminathan B, et al.
PLoS ONE (2014)
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, et al.
The Journal of Clinical Investigation (2010)
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