SAB1300996

Anti-PRL1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-PTP4A1 protein, Anti-Tyrosine phosphatase, Hypothetical protein DKFZp779M0721, Protein tyrosine phosphatase type IVA(member 1)
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: 1:1000
• NCBI accession no.: NP_003454.1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PRL1(7803)

Description

General description

Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1), also known as protein tyrosine phosphatase type IVA, member 1 (PTP4A1), is encoded by the gene mapped to human chromosome 6q12. The encoded protein is a member of a small class of prenylated protein tyrosine phosphatases (PTPs). It is characterized by a PTP domain and a specific C-terminal prenylation motif. PRL1 is mainly localized to the cell membrane and the endoplasmic reticulum depending on its C-terminal prenylation.

Immunogen

PRL1 (NP_003454.1, 1-200)
This antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1.

Biochem/physiol Actions

Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) regulates cancer-related signaling pathways, which are downstream of epidermal growth factor receptor (EGFR) pathway and stimulates cell proliferation, invasion and migration. PRL1 acts as a potential therapeutic target and predictor for patient survival in prostate cancer (PCa) including those with castration-resistant prostate cancer (CRPC). PRL1 is essential for normal mitotic process. Elevated expressions of prenylated protein tyrosine phosphatases (PTPs) in mammalian cells conferred a transformed phenotype, which might be involved in the tumorigenesis.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable