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SAB1300960

Sigma-Aldrich

Anti-MEKK3 (center) antibody produced in rabbit

Ig fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-MAP3K3, Anti-MAPK/ERK kinase kinase 3, Anti-MEK kinase 3, Anti-MEKK 3, Anti-Mitogen-activated protein kinase kinase kinase 3

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

NP_976226

UniProt accession no.

Q99759

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... MEKK3(4215)

General description

MEKK3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhances transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway.

Immunogen

MEKK3 (NP_976226, 241-275)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human MEKK3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Xue-Quan Cao et al.
Asian Pacific journal of cancer prevention : APJCP, 15(13), 5271-5276 (2014-07-22)
Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) is an important protein kinase and a member of the MAPK family, which regulates cellular responses to environmental stress and serves as key integration points along the signal transduction cascade that
Nayara I Viana et al.
The International journal of biological markers, 29(3), e246-e252 (2014-01-30)
The aim of this study was to analyze the roles of miR-143 and miR-145, as well as the gene and protein expression of their targets (KRAS, ERK5, MAP3K3, and MAP4K4) in the pathogenesis of benign prostatic hyperplasia (BPH). We analyzed

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