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SAB1300869

Anti-THPO (C-term) antibody produced in rabbit

Name: Anti-THPO (C-term) antibody produced in rabbit
Brand: SIGMA

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym(s):

Anti-C-mpl ligand, Anti-ML, Anti-Megakaryocyte colony-stimulating factor, Anti-Thrombopoietin, Myeloproliferative leukemia virus oncogene ligand

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

NP_000451

UniProt accession no.

P40225

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... THPO(7066)

General description

Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. It is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It is an acidic glycoprotein. The gene encoding it is localized on human chromosome 3q27.1.

Immunogen

THPO (NP_000451, 305-339)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the C-term of human THPO.

Biochem/physiol Actions

Thrombopoietin (TPO) stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the cellular proto-oncogene (c-mpl) receptor and acts as an important regulator of circulating platelets. High levels of TPO have been observed in patients with aplastic anemia. Human and murine TPO exhibits cross-species reactivity.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The molecular mechanisms that control thrombopoiesis.

Kaushansky K

The Journal of Clinical Investigation, 115(12), 3339-3347 (2005)

Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia.

Majed J Dasouki et al.

Blood, 122(20), 3440-3449 (2013-10-03)

We recently identified 2 siblings afflicted with idiopathic, autosomal recessive aplastic anemia. Whole-exome sequencing identified a novel homozygous missense mutation in thrombopoietin (THPO, c.112C>T) in both affected siblings. This mutation encodes an arginine to cysteine substitution at residue 38 or

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