Parkinson is the second most common neurodegenerative disease after Alzheimer’s. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson′s disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson′s disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
The previously assigned protein identifier Q961J3 has beenmerged into Q0KHV6. Full details can be found on the UniProt database.
Immunogen
PARK6 (NP_572340, ) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila PARK6.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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