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Key Documents

SAB1300783

Sigma-Aldrich

Anti-CLC4 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-CLCN4, Anti-Chloride channel protein 4, Anti-ClC-4

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100 μG
$455.00

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100 μG
$455.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$455.00

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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000
indirect immunofluorescence: 1:10-1:50
western blot: 1:100-1:500

NCBI accession no.

NP_001821

UniProt accession no.

P51793

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLC4(1183)

General description

CLCN4 (chloride channel 4) gene codes for the chloride/hydrogen ion exchanger CIC-4. It is abundantly expressed in brain. ClC-4 belongs to the ClC transporter branch. It is present in the intracellular membranes of the brain, muscle and liver. This gene is located on human chromosome Xp22.3.

Immunogen

CLC4 (NP_001821, 662-699)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CLC4.

Biochem/physiol Actions

CLCN4 (chloride channel 4) is associated with X-linked intellectual disability and epilepsy. ClC-4 helps to interchange anion/proton with variable stoichiometry.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
020M2163

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Channel-like slippage modes in the human anion/proton exchanger ClC-4.
Alekov AK and Fahlke C
The Journal of General Physiology, 133(5), 485-496 (2009)
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer EE, et al.
Molecular Psychiatry, 23(2), 222?230-222?230 (2016)
Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes.
Craig IW, et al.
European Journal of Human Genetics, 12(8), 639-639 (2004)

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