Pre-mRNA splicing occurs in two sequential transesterification steps. PRP17 is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. PRP17 has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.
Immunogen
PRP17 (NP_056975, 369-403) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human PRP17.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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