The gene ELP3 (elongator complex protein 3) is mapped to human chromosome 8p21.1. The encoded protein has a HAT (histone acetyltransferase) domain.
Immunogen
ELP3 (NP_060561, 14-54) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ELP3.
Biochem/physiol Actions
ELP3 (elongator complex protein 3) is a catalytic subunit of the histone acetyltransferase elongator complex. It enhances histone H3 acetylation, thereby regulating gene regulation in neurons. Dysregulation of ELP3 activity causes neuronal disorders, such as familial dysautonomia and amyotrophic lateral sclerosis. It might be a potential acetyltransferase for glucose-6-phosphate dehydrogenase. The ELP3 gene promoter is hypermethylated in invasive ductal breast carcinoma, causing transcriptional inactivation of the gene.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.
Davidsson J, et al.
Epigenetics & Chromatin, 6, 18-18 (2013)
hElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity.
Li F, et al.
PLoS ONE, 6, e29303-e29303 (2011)
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.
Wang YP, et al.
The Embo Journal, 33, 1304-1320 (2014)
The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila.
Singh N, et al.
Journal of Neurochemistry, 115, 493-504 (2010)
Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.
Wang D
Molecular and Cellular Biochemistry, 396, 67-77 (2014)
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