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SAB1300349

Sigma-Aldrich

Anti-Mouse Pcp2 (C-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym(s):

Anti-Pcp-2, Anti-Pcp2, Anti-Protein PCD-5, Anti-Purkinje cell protein 2, Anti-Purkinje cell-specific protein L7

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse

technique(s)

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

NCBI accession no.

NP_032816

UniProt accession no.

P12660

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Pcp2(18545)

General description

Pcp2 may function as a cell-type specific modulator for G protein-mediated cell signaling. PCP2 (Purkinje cell protein 2) codes for a protein belonging to the GoLoco domain-containing family. Pcp2 is specifically localized to cerebellum in the Purkinje cells and in retinal bipolar cells. From Pcp2 protein structural analysis, it is known that Pcp2 contains two GoLoco motifs.

Immunogen

PCP2 (NP_032816, )
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse Pcp2.

Biochem/physiol Actions

Pcp2 might serve as an inhibitor of guanine nucleotide dissociation.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).
Willard F S, et al.
Cellular Signalling, 18(8), 1226-1234 (2006)
Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response.
Xu Y, et al.
The Journal of Neuroscience, 28(36), 8873-8884 (2008)

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