Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP11 may play an important role in the progression of epithelial malignancies. It is specifically expressed in stromal cells of breast carcinomas.
Immunogen
MMP11 (MM11_HUMAN, 403-436) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MMP11.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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