SAB1300242

Anti-dcr-1 (center) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-Dcr-1, Anti-Endoribonuclease dcr-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: Caenorhabditis elegans
• technique(s): indirect ELISA: 1:1000
• NCBI accession no.: NP_498761
• UniProt accession no.: P34529
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: Caenorhabditis elegans ... Dcr-1(176138)

Description

General description

The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III.
DCR-1 (dicer 1, ribonuclease III) is an RNase ΙΙΙ endoribonuclease. It is located on human chromosome 14q32.

Immunogen

DCR (NP_498761, 1008-1042)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of C. elegans Dcr-1.

Biochem/physiol Actions

Dcr-1 is required both for RNA interference and for the synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
DCR-1 (dicer 1, ribonuclease III) has the ability to cleave dsRNA into smaller fragments that mediate RNAi. It plays an important role in miRNA processing and participates in innate immunity. DCR-1 is essential for the production of endo-siRNAs implicated in gene silencing and epigenetic modulation.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable