SAB1300049

Anti-Noxa BH3 Domain antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-Immediate-early-response protein APR, Anti-PMA-induced protein 1, Anti-PMAIP1, Anti-PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: 1:1000
• NCBI accession no.: NP_066950
• UniProt accession no.: Q13794
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NOXA(5366)

Description

General description

The expression of the Noxa gene, a BH3 only member of the Bcl2 family, involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Co-immunoprecipitation data suggests that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. Blocking endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis, suggesting that Noxa may mediate p53 dependent apoptosis.

Immunogen

NOXA (NP_066950, 12-52)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region (BH3 domain) of human Noxa.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable