Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. In yeast this protein has been shown to regulate chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics.
Immunogen
SUMO (NP_010798, 1-30) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of yeast SUMO.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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