SAB1300003

Monoclonal Anti-SET07 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-H4-K20-HMTase, Anti-Histone H4-K20 methyltransferase, Anti-PR/SET07, PR/SET domain-containing protein 07, SET domain-containing protein 8
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 43AT551.86, monoclonal
• form: buffered aqueous solution
• species reactivity: mouse, human
• technique(s): indirect ELISA: 1:1000; western blot: 1:100-1:500
• isotype: IgG1
• NCBI accession no.: AAF97812
• UniProt accession no.: Q9NQR1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SET07(387893)

Description

General description

SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.

Immunogen

SET07 (AAF97812, N Terminal)
This antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07.

Physical form

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable