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Key Documents

SAB1103067

Sigma-Aldrich

Anti-FAM83A (232-245) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-BJ-TSA-9, Anti-Family with sequence similarity 83, member A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~47 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

Q86UY5

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... FAM83A(84985)

General description

The gene family with sequence similarity 83 member A (FAM83A) is mapped to human chromosome 8q24. It is overexpressed in lung, testis and bladder cancer.[1] The protein has DUF1669 (domain of unknown function 1669), serine-rich domains and proline-rich domains (PRDs).[2]

Immunogen

synthetic peptide corresponding to amino acids 232-245 of human FAM83A

Application

Anti-FAM83A (232-245) antibody produced in rabbit has been used in Western blotting.[1]

Biochem/physiol Actions

Family with sequence similarity 83 member A (FAM83A) is a cancer associated gene. It is upregulated in breast cancer and is associated with resistance to EGFR (epidermal growth factor receptor)–tyrosine kinase inhibitors.[2] It associates with c-RAF (serine/threonine protein kinase) and phosphatidylinositol 3 kinase p85, thereby resulting in the activation of EGFR/phosphatidylinositol 3 kinase/AKT (serine/threonine kinase) signaling route.[1]

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
021M2772

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FAM83A confers EGFR-TKI resistance in breast cancer cells and in mFAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.ice.
Lee SY, et al.
The Journal of Clinical Investigation, 122, 3211-3220 (2012)
FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer.
Chen S, et al.
Oncogenesis, 6 (2017)
S Chen et al.
Oncogenesis, 6(3), e300-e300 (2017-03-14)
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), contribute to tumorigenesis, resistance to chemoradiotherapy and recurrence in human cancers, suggesting targeting CSCs may represent a potential therapeutic strategy. In the current study, we found family with sequence similarity
Junfen Xu et al.
International journal of oncology, 57(2), 509-521 (2020-07-07)
Family with sequence similarity 83 member A (FAM83A) has been recently observed to be upregulated in various types of cancer and hypothesized to be serve as an oncogene. The present study aimed to determine the functional roles and the underlying molecular

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