Heat shock protein family B (small) member 3 (HSPB3) is a member of HSPB family. It is expressed in skeletal and cardiac muscles. HSPB3 gene is located on human chromosome location 5q11.2.
Immunogen
synthetic peptide corresponding to amino acids 11-25of human HSPB3
Application
Anti-HSPB3 (11-25) antibody produced in rabbit has been used in western blotting and immunoelectron microscopy.
Biochem/physiol Actions
Heat shock protein family B (small) member 3 (HSPB3) has molecular chaperone-like activity in inhibiting the heat-induced aggregation of alcohol dehydrogenase (ADH). HSPB is critical for the development and maintenance of muscles. Mutations in HSPB3 are associated with distal hereditary motor neuropathy type 2C (dHMN2C).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The ten mammalian small heat shock proteins (sHSPs/HSPBs) show a different expression profile, although the majority of them are abundant in skeletal and cardiac muscles. HSPBs form hetero-oligomers and homo-oligomers by interacting together and complexes containing, e.g., HSPB2/HSPB3 or HSPB1/HSPB5
The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells
Piccolella M, et al.
Oncotarget, 8(6), 10400-10400 (2017)
An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8
Cell biochemistry and biophysics, 64(1), 61-72 (2012-05-23)
HspB3, an as yet uncharacterized sHsp, is present in muscle, brain, heart, and in fetal tissues. A point mutation correlates with the development of axonal motor neuropathy. We purified recombinant human HspB3. Circular dichroism studies indicate that it exhibits β-sheet
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
