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SAB1100655

Sigma-Aldrich

Anti-VCP (311-325) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-IBMPFD, Anti-TERA, Anti-Valosin-containing protein, Anti-p97

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~89 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1:500-1:2,000

UniProt accession no.

P55072

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VCP(7415)

General description

Valosin containing protein (VCP/ p97), a cytosolic protein, has 806 amino acids and is abundantly expressed in the brain. VCP belongs to the AAA (ATPase associated with various cellular activities) ATPase family. VCP gene is mapped to human chromosome 9p13.3.

Immunogen

synthetic peptide corresponding to amino acids 311-325 of human VCP

Application

Anti-VCP (311-325) antibody produced in rabbit has been used in western blotting.[1]
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Valosin containing protein (VCP/ p97) serves as segregase or unfoldase for conformational changes of target proteins. It participates in transcriptional control, endoplasmic reticulum-associated degradation (ERAD), homotypic membrane fusion, autophagy and endosomal sorting. It also regulates the cell cycle and degradation of protein at the outer mitochondrial membrane. Mutations on VCP gene results in amyotrophic lateral sclerosis (ALS).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
129K2735

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VCP (valosin containing protein)
Erzurumlu Y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2020)
A P Moss et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 97(5), 906-908 (1979-05-01)
Thirty employees of an industrial plant involved in the manufacture of silver nitrate and silver oxide underwent ophthalmologic evaluation in an effort to evaluate the frequency and extent of ocular argyrosis. The most frequently noted ocular abnormality was pigmentation of
Ashley E Gonzalez et al.
Frontiers in cell and developmental biology, 8, 256-256 (2020-05-07)
Valosin-containing protein (VCP), also called p97, is an evolutionarily conserved and ubiquitously expressed ATPase with diverse cellular functions. Dominant mutations in VCP are found in a late-onset multisystem degenerative proteinopathy. The neurological manifestations of the disorder include frontotemporal dementia (FTD)

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