S9442
Anti-Synaptopodin (SE-19) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
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biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 100 kDa
species reactivity
rat
technique(s)
microarray: suitable
western blot: 1:3,000 using cytosolic S1 fraction of rat brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SYNPO(11346)
rat ... Synpo(60324)
Related Categories
General description
Synaptopodin is a proline-rich, actin-associated protein (100 kDa) is present in the post-synaptic density (PSD) in actin cytoskeleton. It is also present in the dendritic spines and differentiated podocytes. Synaptopodin contains a high amount of proline residues (~20%), which are evenly distributed along the protein sequence, thus virtually excluding the formation of globular domains. In particular, synaptopodin does not contain functional domains found in receptor clustering PSD proteins. Sequence comparison between human and mouse synaptopodin shows 84% identity. The exclusive site of synaptopodin expression in the telencephalon is restricted to specific areas of high synaptic plasticity, i.e. in the perykaria of the olfactory bulb, striatum, and hippocampus.
Immunogen
synthetic peptide corresponding to amino acids 184-202 of rat synaptopodin conjugated to KLH. This rat synaptopodin sequence has ~70% identity with human synaptopodin.
Application
Anti-Synaptopodin (SE-19) antibody produced in rabbit has been used in:
- immunofluorescence microscopy
- immunohistochemistry
- western blotting
Biochem/physiol Actions
Synaptopodin is thought to play an important role in synaptic plasticity and is associated in the modulation of motility of actin in neuronal dendritic spines. The association of synaptopodin with the specialized actin system of renal podocyte foot processes suggests that it may play a role in actin cytoskeleton dynamics of these cellular extensions. Synaptopodin has been found to interact with α-actinin-4 and the tight junction protein Membrane-associated guanylate kinase inverted 1 (MAGI-1) in Madin-Darby Canine Kidney (MDCK) cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Synaptopodin is regulated by aromatase activity
Fester L, et al.
Journal of Neurochemistry, 140(1), 126-139 (2017)
Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy
Roth SU, et al.
Brain Pathology, 11(2), 169-181 (2001)
Alberto Perez-Alvarez et al.
Nature communications, 11(1), 5083-5083 (2020-10-10)
In hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines contain just a single tubule of smooth ER. Here we show that the ER
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes
Mundel P, et al.
The Journal of cell biology, 139(1), 193-204 (1997)
A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice
Wang XX, et al.
Test, 292(29), 12018-12024 (2017)
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