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S9399

Sigma-Aldrich

Staphylococcal enterotoxin A

from Staphylococcus aureus, lyophilized powder, enterotoxin

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About This Item

CAS Number:
642595-84-4
MDL number:
MFCD00082015
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name

Staphylococcal enterotoxin A from Staphylococcus aureus,

contains

sodium phosphate buffer as balance

Quality Level

200

composition

Protein, ~10% Lowry

availability

not available in USA

impurities

Staphylococcal enterotoxin B (SEB), essentially free

solubility

H2O: complete 1 mg/ml, clear, colorless

storage temp.

2-8°C

General description

Staphylococcal enterotoxin A belongs to the family of staphylococcal exotoxins. It is secreted by Staphylococcus aureus, a Gram-positive bacteria.[1]

Application

Staphylococcal enterotoxin A from Staphylococcal aureus was injected peritoneally in mice to induce sepsis.10
Staphylococcal enterotoxin A from Staphylococcus aureus has been used as an external standard in for the verification of TRANSIA assay kit, RIDASCREEN assay kit and Vidas Set 2 method.[2] For in vitro toxin stimulation of mouse splenocytes.[3]

Biochem/physiol Actions

Staphylococcal enterotoxin A from Staphylococcus aureus is leading agent that causes of food poisoning. A concentration of as little as 0.5 mg/ml is sufficient to result in nausea, vomiting, diarrhea and cramps.8 It stimulates the cell proliferation of peripheral lymphocytes, induces the production of interferons and is important for gut immunity against S. aureus infections.9 It acts as a super antigen for T-lymphocytes.

Packaging

Package size based on protein content

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GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000367998
0000367997
0000367998
0000367997
0000211643

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Dong Zhang et al.
Oncoimmunology, 9(1), 1744921-1744921 (2020-04-22)
T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctional and exhausted T
Staphylococcal Enterotoxins
<BIG>Pinchuk IV, et al.</BIG>
Toxins, 2, 2177-2177 (2010)
Determination of staphylococcal enterotoxins in cheese by immunoenzyme assays
<BIG>Jankovic V, et al.</BIG>
Archives of Biological Sciences, 64, 1449-1454 (2012)
Marcin Kłak et al.
Scandinavian journal of infectious diseases, 42(5), 351-358 (2010-01-27)
Haemostatic balance shifts towards pro-coagulation during infection. Plasminogen, a key molecule of fibrinolysis, may play an important role in the pathogenesis of staphylococcal infections. In the present study, we assessed the impact of inhibition of plasminogen activation by tranexamic acid
Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6
<BIG>Martinez F, et al.</BIG>
The Journal of Infectious Diseases, 209, 1077-1086 (2013)
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