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S8939

Sigma-Aldrich

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

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2 μG
$765.00

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2 μG
$765.00

About This Item

MDL number:
MFCD03458482
UNSPSC Code:
51111800
NACRES:
NA.32

$765.00

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Request a Bulk Order

recombinant

expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)

Quality Level

200

form

buffered aqueous solution

mol wt

~48 kDa by SDS-PAGE

UniProt accession no.

O00141

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SGK1(6446)

General description

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family[1] and the gene encoding it is localized on human chromosome 6q23.[2]

Biochem/physiol Actions

Kinase assays.
The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.[3][4]

Unit Definition

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

Legal Information

Brij is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

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Certificates of Analysis (COA)

Lot/Batch Number
071K0246

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Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables
David W Ellison
Journal of Clinical Oncology (2011)
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
Ferrelli F
Acta Diabetologica (2015)
mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
Feng Hong
Molecular Cell, 30(6) (2011)
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.
Talarico C
Cellular Physiology and Biochemistry (2016)

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