Skip to Content
MilliporeSigma
All Photos(1)

Documents

S8689

Sigma-Aldrich

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

Synonym(s):

SuperFas Ligand™

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD01092558
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

human

Quality Level

200

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-GE)

form

lyophilized powder

mol wt

32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

technique(s)

ligand binding assay: suitable

UniProt accession no.

P48023

storage temp.

−20°C

Gene Information

human ... FASLG(356)

Application

ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service