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S8647

Sigma-Aldrich

Sulfacetamide sodium salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C8H9N2NaO3S · H2O
CAS Number:
6209-17-2
Molecular Weight:
254.24
MDL number:
MFCD00149555
UNSPSC Code:
51102829
PubChem Substance ID:
24899806
NACRES:
NA.85

form

powder

color

white to off-white

solubility

H2O: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

mode of action

DNA synthesis | interferes
enzyme | inhibits

SMILES string

NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O

InChI

1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1

InChI key

IHCDKJZZFOUARO-UHFFFAOYSA-M

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General description

Chemical structure: sulfonamide

Biochem/physiol Actions

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Packaging

100G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000080723
088M4754V
107M4763V
116M4760V
066M4778V

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Ilknur Akyol-Salman et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(1), 49-52 (2011-07-15)
This study aimed to compare the efficacy of topical N-acetyl-cysteine (NAC) with a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with meibomian gland dysfunction (MGD). Twenty patients with MGD were prospectively randomized and assigned into 2 groups. The patients
Zoe Diana Draelos
Journal of drugs in dermatology : JDD, 9(3), 234-236 (2010-03-18)
Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of these is the combination 10% sodium sulfacetamide and 5% sulfur. Sodium
James Q Del Rosso
Cutis, 86(5 Suppl), 16-25 (2011-01-15)
Rosacea is a prevalent inflammatory skin disorder that affects approximately 16 million individuals in the United States. Although its exact etiology is unknown, basic science, histologic evidence, and clinical evidence suggest that it is inflammatory in nature. In this 12-week
Meghan I Dubina et al.
Archives of dermatology, 145(9), 1027-1029 (2009-09-23)
A recent study demonstrated evidence of a yellow-orange discoloration of the skin and hair when topical dapsone gel was combined with benzoyl peroxide. This phenomenon had previously been observed by one of us (A.B.F.) when sulfasalazine was combined with benzoyl
Rade Injac et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 424-431 (2008-03-19)
A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmol l(-1) borate, 20 mmol l(-1) phosphate, pH 8.4, containing 20 mmol l(-1)
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