S5822

Spergualin trihydrochloride

>95% (HPLC and TLC), from Bacillus laterosporus

• Synonym(s): Antibiotic BMG 162aF2, Heptanamide,7-[(aminoiminomethyl)amino]-N-[(1S)-2-[[4-[(3-aminopropyl)amino]butyl]amino]-1-hydroxy-2-oxoethyl]-3-hydroxy-,3S)-trihydrochloride
• Empirical Formula (Hill Notation): C₁₇H₄₀Cl₃N₇O₄
• CAS Number: 80952-47-2
• Molecular Weight: 512.90
• UNSPSC Code: 12352200

Properties

• biological source: Bacillus laterosporus
• assay: >95% (HPLC and TLC)
• storage condition: desiccated
• solubility: H₂O: soluble; acetone: insoluble; ethanol: insoluble; ethyl acetate: insoluble; methanol: soluble
• antibiotic activity spectrum: neoplastics
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C17H37N7O4.3ClH/c18-7-5-9-21-8-3-4-10-22-15(27)16(28)24-14(26)12-13(25)6-1-2-11-23-17(19)20;;;/h13,16,21,25,28H,1-12,18H2,(H,22,27)(H,24,26)(H4,19,20,23);3*1H/t13-,16-;;;/m0.../s1
• InChI key: XWNJZPKETIWTTF-RIHGSVRJSA-N

Description

Application

Spergualin trihydrochloride was used to compare the 15-deoxyspergualin, a derivative of spergualin by thin layer chromatography.¹

Biochem/physiol Actions

Spergualin is an antibiotic isolated from Bacillus laterosporus that has antibacterial, antitumor, and strong immunosuppressive properties. Spergualin exhibits antitumor activity against transplantable leukemias in mice such as lymphatic leukemia L1210, monocytic leukemia P388, mastocytoma P815, or thymoma EL-4. Spergualin was found effective in inhibiting skin graft rejection, preventing GVHD (Graft-Versus-Host-Disease) in mice recipients of allogeneic bone marrow and spleen cells, and modulating other immunologic diseases.

Spergualin is an antibiotic that posses antibacterial, antitumor, and strong immunosuppressive properties.

Preparation Note

Spergulain is very soluble in water and methanol. It is slighly or not soluble in ethanol, ethyl acetate, acetone cyclohexane, and other organic solvents. Spergualin solutions are unstable at acidic pH (pH <2) and at highly alkaline pH (pH >9). The powder is highly hygroscopic.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves