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S3826

Sigma-Aldrich

Staphostatin B from Staphylococcus aureus

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

recombinant

expressed in E. coli

Quality Level

200

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

Staphostatins are a novel group of inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Staphostatin A and staphostatin B from S. aureus have been characterized in details. Staphostatins interact specifically with this target proteinases forming tight 1:1 and stable non-covalent complex, staphostain A with staphopain A and staphostain B with staphopain B with no cross interaction observed and with very narrow specificity limited to staphopains
The loss of staphostatin B (SspC) expression in S. aureus and the subsequent increase in secreted protease staphopain B (SspB) activity resulted in numerous defects including reduced growth, decreased autolytic activity, resistance to lysis by S. aureus phages, and the inability to secrete proteins into the extracellular matrix. [1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
050M1417

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Lindsey N Shaw et al.
Journal of bacteriology, 187(5), 1751-1762 (2005-02-18)
The cytoplasmic protein SspC of Staphylococcus aureus, referred to as staphostatin B, is a very specific, tightly binding inhibitor of the secreted protease staphopain B (SspB). SspC is hypothesized to protect intracellular proteins against proteolytic damage by prematurely folded and

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