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About This Item
Empirical Formula (Hill Notation):
C79H107ClN14O17
Molecular Weight:
1560.23
MDL number:
UNSPSC Code:
12352200
solubility
H2O: >10 mg/mL
storage temp.
−20°C
Amino Acid Sequence
Ac-Nal-Cpa-Trp-Ser-Tyr-Lys-DHP-Leu-Lys-DHP-Pro-Ala-NH2
Application
SDZ-216,887 may be used in LH-RH-mediated cell signaling studies.
Biochem/physiol Actions
SDZ-216,887 blocks the effects of endogenous Luteinizing hormone-releasing hormone (LH-RH) and inhibits the gene expression of pituitary LH-RH receptors.
Features and Benefits
This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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M Kovacs et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1829-1834 (2001-02-15)
The mechanisms through which LH-RH antagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely understood. To elucidate these mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in
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