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S2941

Sigma-Aldrich

SKF-75670 hydrobromide

>98% (HPLC), solid

Synonym(s):

7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C17H19NO2 · HBr
CAS Number:
62717-63-9
Molecular Weight:
350.25
MDL number:
MFCD11045981
UNSPSC Code:
12352200
PubChem Substance ID:
24278700

assay

>98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 12 mg/mL
H2O: insoluble

SMILES string

Br.CN1CCc2cc(O)c(O)cc2C(C1)c3ccccc3

InChI

1S/C17H19NO2.BrH/c1-18-8-7-13-9-16(19)17(20)10-14(13)15(11-18)12-5-3-2-4-6-12;/h2-6,9-10,15,19-20H,7-8,11H2,1H3;1H

InChI key

KWTPHNVUAVFKGB-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

SKF-75670 may be used in dopamine and cocaine-mediated cell signaling studies.

Biochem/physiol Actions

Atypical D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.
SKF-75670 is a selective dopamine D1 receptor agonist but with lower efficacy.[1] It also acts as cocaine antagonist and alters the behavioral effects of cocaine in squirrel monkeys.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
093K4625
032K4708

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R D Spealman et al.
Psychopharmacology, 133(3), 283-292 (1997-11-15)
Dopamine D1 agonists differing in efficacy with respect to stimulation of adenylate cyclase activity and other in vitro and in vivo criteria were evaluated for their capacity to modulate the behavioral effects of cocaine in squirrel monkeys. Monkeys were trained
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds

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