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S174

Sigma-Aldrich

SDZ-205,557 hydrochloride

solid

Synonym(s):

4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H21ClN2O3 · HCl
CAS Number:
137196-67-9
Molecular Weight:
337.24
MDL number:
MFCD00671790
UNSPSC Code:
12352200
PubChem Substance ID:
24278128
NACRES:
NA.77

form

solid

color

off-white

solubility

DMSO: 100 mg/mL
H2O: 65 mg/mL
ethanol: insoluble

originator

Sandoz

SMILES string

Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC

InChI

1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H

InChI key

JOWUQCJWCRNVMQ-UHFFFAOYSA-N

Gene Information

human ... HTR4(3360)

Biochem/physiol Actions

Potent, selective 5-HT4 serotonin receptor antagonist.

Features and Benefits

This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C M Franks et al.
The Journal of pharmacy and pharmacology, 47(3), 213-218 (1995-03-01)
The involvement of the recently characterized 5-HT4 receptor in the actions of 5-hydroxytryptamine (5-HT) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. 5-HT and the 5-HT1-, 5-HT2- and 5-HT4-receptor agonist 5-methoxytryptamine (5-MeOT), induced a
S Bingham et al.
The Journal of pharmacy and pharmacology, 47(3), 219-222 (1995-03-01)
The ability of 5-hydroxytryptamine (5-HT) to evoke contractile activity in the gastric Heidenhain pouch was measured in conscious dogs using a method in which 5-HT4 receptor-antagonist activity can be measured in-vivo. At doses of 5-HT which evoked short-lived measurable responses
Y Nagakura et al.
The Journal of pharmacology and experimental therapeutics, 281(1), 284-290 (1997-04-01)
We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to modify 5-HT-accelerated colonic transit in conscious rats, but the 5-HT3 and 5-HT4 receptor dual antagonist FK1052 prevented the enhancement. In this study, the inhibitory effect on the stimulated colonic
J Lorrain et al.
European journal of pharmacology, 229(1), 105-108 (1992-12-08)
Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by
N Amemiya et al.
European journal of pharmacology, 318(2-3), 403-409 (1996-12-30)
This study examined effects of 5-methoxytryptamine (5-MOT), an agonist at 5-HT4 and 5-HT2B receptors, on the contractile response and acetylcholine release in rat stomach fundus strips. 5-MOT (10(-9)-10(-5) M) produced a concentration-dependent increase in the contraction, while it evoked acetylcholine
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