peptide CKIKFAEEDAKPKEKEAGDE corresponding to residues 7-26 of N-terminal rat Accn4.
Target description
Sodium Channel ASIC4 is a member of the ASIC family that also includes ASIC1, ASIC2 and ASIC3. The ASIC family is part of a large channel superfamily known as degenerin/epithelial sodium channels (DEG/ENaC). The functional ASIC channel is composed of 4 subunits, which can form either a homo or heterotetramer. ASIC4 protein does not appear to function as a proton-gated channel when expressed alone in heterologous systems and therefore a modulatory role for this subunit has been proposed. ASIC4 protein is expressed in brain, pituitary gland, spinal cord and inner ear.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Reconstitution
Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
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