immunohistochemistry (formalin-fixed, paraffin-embedded sections): 24 μg/mL using human pancreas, Islets of Langerhans (Optimal dilution should be determined by the researcher.)
Somatostatin receptor 2 (SSTR2) is encoded by the gene mapped to human chromosome 17q25.1. It is mainly localized on choroid plexus and arachnoid granulations. SSTR2 is transcribed into two isoforms, SSTR2A and SSTR2B through alternative splicing.
Immunogen
synthetic peptide corresponding to the second extracellular loop of human somatostatin receptor type 2, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Biochem/physiol Actions
Somatostatin receptor 2 (SSTR2) mediates human anterior pituitary hormone suppression by interacting with its peptide ligand somatostatin. It also plays a major role in maintenance of brain fluid homeostasis. The encoded protein has an ability to hinder the cell proliferation of solid tumors. Experimental studies states that SSTR2 methylation is presumed to be involved in the metastasis and invasion of laryngeal cancer.
Genetic analysis of inherited hydrocephalus in a rat model
Jones HC, et al.
Experimental Neurology, 190, 79-90 (2004)
SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males
Shen Z, et al.
Diagnostic Pathology (2016)
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